Descarga: Platelet pathology and antiplatelet strategies
Archivo: eha/plaquetopatias/haemo 2016 Platelet pathology and antiplatelet strategies.pdf
Blood platelets were the focus of recent issues of this Journal (1, 2). Why do these inconspicuous, small cellular fragments, derived from megakaryocytes in the bone marrow, gain so much attention both in clinical settings and basic science? Platelets contribute essentially to survey the integrity of the vascular system by becoming adherent within milliseconds and by forming platelet aggregates at sites of injured endothelial cells or exposed subendothelial matrix structures (3). Overall, platelets play a pivotal role in hemostasis. However, once stimulated, platelets respond uniformly and do not distinguish between traumatic injury and vascular lesions caused by variety of clinical disorders (4). Thus, under pathological conditions, mechanisms otherwise beneficial for hemostasis and vascular integrity may cause occlusive thrombi and, subsequently, acute ischemic syndromes of the heart, brain and other organ systems (5, 6).
Documento PDF detectado.