Descarga: Type 2M and Type 2A von Willebrand Disease: Similar but Different
Archivo: eha/vonwill/STH 2016 2M vs 2A VWD.pdf
Analogous to the differentiation between hemophilia A and B, respectively, reflecting deficiency in factor VIII (FVIII) and FIX, and increasing being recognized as reflecting clinicallydifferentdisorders,types2Aand2MvonWillebranddisease(VWD)canalsobe shown to express both similarities and differences in their prevalence, genetic defects, laboratory test results, clinical features, and treatment responses. In this narrative review, we explore these two “subtypes” of type 2 VWD, identifying parallels and dissimilarities in various aspects of their presentation to clinicians and to scientists/ laboratories.Thisdifferentialwillbecomeincreasinglyimportantaswestrivetoprovide personalized approaches to future management of patients with VWD, particularly in the emerging landscape of recombinant von Willebrand factor.
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