Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia

Descarga: Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia Archivo: tromboembolia-venosa/tvp/th_2016-Clinical picture of HITand its differentiation from non-HIT thrombocytopenia.pdf HIT is an acquired antibody-mediated disorder strongly associated with thrombosis, including microthrombosis secondary to disseminated intravascular dissemination (DIC). The clinical features of HIT are reviewed from the perspective of the 4Ts scoring…

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Management of the multiple phases of heparin-induced thrombocytopenia

Descarga: Management of the multiple phases of heparin-induced thrombocytopenia Archivo: tromboembolia-venosa/tvp/th_2016-Management of the multiple phases of heparin-induced thrombocytopenia.pdf The clinical course of heparin-induced thrombocytopenia (HIT) may be separated into five sequential phases: 1. suspected HIT, 2. acute HIT, 3. subacute HIT A, 4. subacute HIT B, and 5. remote HIT. Each phase confronts the clinician…

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Role of monocytes and endothelial cells in heparin-induced thrombocytopenia

Descarga: Role of monocytes and endothelial cells in heparin-induced thrombocytopenia Archivo: tromboembolia-venosa/tvp/th_2016-Role of monocytes and endothelial cells in heparin-induced thrombocytopenia.pdf Heparin-induced thrombocytopenia (HIT) is an autoimmune disorder characterised by thrombocytopenia and thrombosis. The mechanisms leading to platelet destruction are complex and the thrombotic complications of HIT appear to be due to multiple different intravascular targets….

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Cancer-associated venous thromboembolism: Burden, mechanisms, and management

Descarga: Cancer-associated venous thromboembolism: Burden, mechanisms, and management Archivo: tromboembolia-venosa/tvp/th_2017-Cancer-associated venous thromboembolism.pdf Venous thromboembolism (VTE) is a significant health problem in the general population but especially in cancer patients. In this review, we discuss the epidemiology and burden of the disease, the pathophysiology of cancer-associated VTE, and the clinical treatment options for both primary prevention…

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Cirrhosis as a risk factor for venous thrombosis

Descarga: Cirrhosis as a risk factor for venous thrombosis Archivo: tromboembolia-venosa/tvp/th_2017-Cirrhosis as a risk factor for venous thrombosis.pdf Chronic and acute liver diseases have long been considered as the epitome of acquired bleeding disorders. Evidence in support of this included profoundly abnormal test results of routine diagnostic tests of haemostasis in combination with clinical bleeding…

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A Brief Historical Review of the Waterfall/Cascade of Blood Coagulation

Descarga: A Brief Historical Review of the Waterfall/Cascade of Blood Coagulation Archivo: historia/Historia cascada coagulacion.pdf This article explores some of the events and people involved in unraveling the basic mechanisms leading to the clotting of blood. It also brings to focus the important role that my teachers and colleagues had on my career in research….

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The history of haemophilia

Descarga: The history of haemophilia Archivo: historia/IngramHistoria Hemofilia1976.pdf The history of haemophilia shows the human mind attempting to define and encompass a mysterious yet fascinating phenomenon; and also the human heart responding to the challenge of repeated adversity. These responses have not remained isolated but have frequently interacted. As doctors have studied haemophilia in order…

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Oxford, the Mecca for blood coagulation research in the 1950s and 1960s

Descarga: Oxford, the Mecca for blood coagulation research in the 1950s and 1960s Archivo: historia/OxfordLa Meca de lacoagulacion.pdf Gwyn Macfarlane was undoubtedly the instigator of blood coagulation research at Oxford during the last century. From his earliest paper in 1931 on a survey of hemophilia [1], he engendered an interest in the diagnosis and treatment…

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The various states of von Willebrand factor and their function in physiology and pathophysiology

Descarga: The various states of von Willebrand factor and their function in physiology and pathophysiology Archivo: eha/vonwill/th_2014-The various states of VWF and their function2.pdf The specific interactions of von Willebrand factor (VWF) with the vessel wall, platelets or other interfaces strongly depend on (a shearinduced) VWF activation. Shear flow has been shown to induce a…

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