Descarga: Clinical trials with new direct oral anticoagulants Archivo: tromboembolia-venosa/tvp/Phlebologie 03_2013 clinical trials DOA.pdf To compare the efficacy and safety of the new direct oral anticoagulants (DOAC), ideally head-to-head clinical trials should be performed. Given the expense of such an undertaking, it is highly unlikely that such a comparison would be performed. Therefore, there is…
Descarga: Diagnosing von Willebrand Disease: A Short History of Laboratory Milestones and Innovations, Plus Current Status, Challenges, and Solutions Archivo: eha/vonwill/STH 2014 Diagnosing von Willebrand Disease.pdf von Willebrand disease (VWD) is a disorder characterized by deficiency of, or defects in, von Willebrand factor (VWF). VWD was originally identified by Erik Adolf von Willebrand, who in…
Descarga: Interference in Coagulation Testing: Focus on Spurious Hemolysis, Icterus, and Lipemia Archivo: tromboembolia-venosa/tvp/STH 2013 Interference in Coagulation Testing.pdf The chance that errors might jeopardize the quality of testing is inherently present throughout the total testing process, especially in the preanalytical phase. In the coagulation laboratory, as well as in other areas of diagnostic testing,…
Descarga: Type 2M and Type 2A von Willebrand Disease: Similar but Different Archivo: eha/vonwill/STH 2016 2M vs 2A VWD.pdf Analogous to the differentiation between hemophilia A and B, respectively, reflecting deficiency in factor VIII (FVIII) and FIX, and increasing being recognized as reflecting clinicallydifferentdisorders,types2Aand2MvonWillebranddisease(VWD)canalsobe shown to express both similarities and differences in their prevalence, genetic…
Descarga: Problems and Solutions in Laboratory Testing for Hemophilia Archivo: tromboembolia-venosa/tvp/STH 2013 Problems and Solutions Lab testing.pdf A diagnosis of hemophilia A or hemophilia B begins with clinical assessment of the patientandisfacilitatedbylaboratorytesting.Theinfluenceofthelatteronadiagnosis ofhemophiliaAorhemophiliaBisclear—adiagnosiscannotbemadewithoutlaboratory confirmation of a deficiency of factor FVIII (FVIII) or factor IX (FIX), respectively. Moreover, the degree of hemophilia severity is specifically characterized…
Descarga: Treatment of von Willebrand Disease Archivo: eha/vonwill/STH 2016 treatment of VWD.pdf Congenital von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS) reflect conditions caused by von Willebrand factor (VWF) deficiency and/or defects.VWDisthemostcommoninheritedbleedingdisorderandAVWSarisesfroma variety of causes. Since VWF stabilizes and protects factor VIII (FVIII) in the circulation, this is also reduced in many patients…
Descarga: Platelet Membrane Glycoproteins: A Historical Review Archivo: tromboembolia-venosa/tvp/STH 2014 Interference in Coagulation Testing.pdf The search for the components of the platelet surface that mediate platelet adhesion andplateletaggregationbeganforearnestinthelate1960swhenelectronmicroscopy demonstrated the presence of a carbohydrate-rich, negatively charged outer coat that was called the “glycocalyx.” Progressively, electrophoretic procedures were developed that identified the major membrane glycoproteins (GP)…
Descarga: Update on antithrombin I (fibrin) Archivo: tromboembolia-venosa/tvp/th_2007-Update on antithrombin I fibrin.pdf Antithrombin I (fibrin) is an important inhibitor of thrombin generation that functions by sequestering thrombin in the forming fibrin clot, and also by reducing the catalytic activity of fibrinbound thrombin.Thrombin binding to fibrin takes place at two classes of non-substrate sites: 1) in…
Descarga: Recombinant clotting factors Archivo: ehh/th_2008-Recombinant clotting factors.pdf The recombinant era for haemophilia began in the early 1980s with the cloning and subsequent expression of functional proteins for both factors VIII and IX. Efficient production of recombinant clotting factors in mammalian cell culture systems required overcoming significant challenges due to the complex post-translational modifications that…
Descarga: Neutrophils in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-Neutrophils in atherosclerosis.pdf Atherosclerosis is a chronic inflammation of the arterial wall and the continuous infiltration of leukocytes into the plaque enhances the progression of the lesion. Because of the scarce detection of neutrophils in atherosclerotic plaques compared to other immune cells, their contribution was largely neglected. However, in the…
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