Descarga: The best of times, the worst of times: a story of haemophilia Archivo: historia/HISTORIA DE LA HEMOFILIA.pdf It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity, it…
Descarga: The history of haemophilia Archivo: historia/IngramHistoria Hemofilia1976.pdf The history of haemophilia shows the human mind attempting to define and encompass a mysterious yet fascinating phenomenon; and also the human heart responding to the challenge of repeated adversity. These responses have not remained isolated but have frequently interacted. As doctors have studied haemophilia in order…
Descarga: Oxford, the Mecca for blood coagulation research in the 1950s and 1960s Archivo: historia/OxfordLa Meca de lacoagulacion.pdf Gwyn Macfarlane was undoubtedly the instigator of blood coagulation research at Oxford during the last century. From his earliest paper in 1931 on a survey of hemophilia [1], he engendered an interest in the diagnosis and treatment…
Descarga: Problems and Solutions in Laboratory Testing for Hemophilia Archivo: tromboembolia-venosa/tvp/STH 2013 Problems and Solutions Lab testing.pdf A diagnosis of hemophilia A or hemophilia B begins with clinical assessment of the patientandisfacilitatedbylaboratorytesting.Theinfluenceofthelatteronadiagnosis ofhemophiliaAorhemophiliaBisclear—adiagnosiscannotbemadewithoutlaboratory confirmation of a deficiency of factor FVIII (FVIII) or factor IX (FIX), respectively. Moreover, the degree of hemophilia severity is specifically characterized…
Descarga: Treatment of von Willebrand Disease Archivo: eha/vonwill/STH 2016 treatment of VWD.pdf Congenital von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS) reflect conditions caused by von Willebrand factor (VWF) deficiency and/or defects.VWDisthemostcommoninheritedbleedingdisorderandAVWSarisesfroma variety of causes. Since VWF stabilizes and protects factor VIII (FVIII) in the circulation, this is also reduced in many patients…
Descarga: Platelet Membrane Glycoproteins: A Historical Review Archivo: tromboembolia-venosa/tvp/STH 2014 Interference in Coagulation Testing.pdf The search for the components of the platelet surface that mediate platelet adhesion andplateletaggregationbeganforearnestinthelate1960swhenelectronmicroscopy demonstrated the presence of a carbohydrate-rich, negatively charged outer coat that was called the “glycocalyx.” Progressively, electrophoretic procedures were developed that identified the major membrane glycoproteins (GP)…
Descarga: Update on antithrombin I (fibrin) Archivo: tromboembolia-venosa/tvp/th_2007-Update on antithrombin I fibrin.pdf Antithrombin I (fibrin) is an important inhibitor of thrombin generation that functions by sequestering thrombin in the forming fibrin clot, and also by reducing the catalytic activity of fibrinbound thrombin.Thrombin binding to fibrin takes place at two classes of non-substrate sites: 1) in…
Descarga: Recombinant clotting factors Archivo: ehh/th_2008-Recombinant clotting factors.pdf The recombinant era for haemophilia began in the early 1980s with the cloning and subsequent expression of functional proteins for both factors VIII and IX. Efficient production of recombinant clotting factors in mammalian cell culture systems required overcoming significant challenges due to the complex post-translational modifications that…
Descarga: Neutrophils in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-Neutrophils in atherosclerosis.pdf Atherosclerosis is a chronic inflammation of the arterial wall and the continuous infiltration of leukocytes into the plaque enhances the progression of the lesion. Because of the scarce detection of neutrophils in atherosclerotic plaques compared to other immune cells, their contribution was largely neglected. However, in the…
Descarga: New agents for thromboprotection Archivo: tromboembolia-venosa/tvp/haemo_2015-New agents for thromboprotection.pdf Blood coagulation is essential for hemostasis, however excessive coagulation can lead to thrombosis. Factor XII starts the intrinsic coagulation pathway and contact-induced factor XII activation provides the mechanistic basis for the diagnostic aPTT clotting assay. Despite its function for fibrin formation in test tubes, patients…
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