Descarga: Newlocations of intravascular tissue factor Archivo: tromboembolia-venosa/tvp/haemo_2007-New locations of intravascular tissue factor .pdf Tissue factor (TF) is the major initiator of blood coagulation, and a mediator of inflammation, angiogenesis, and carcinogenesis. According to recent evidence, preformed TF and inducible expression of the protein is observed in several blood components. TF is apparently constitutively expressed…
Descarga: Oral anticoagulation with edoxaban Archivo: tromboembolia-venosa/haemo_2012-oral anticoagulation with edoxabanpdf.pdf Edoxaban (the former DU176b) an orally available direct factor Xa inhibitor has been engineered from DX-9065a, which was one of the first parenteral Xa inhibitors. Edoxaban has a time to peak plasma concentrations of 1–2 hours and a half-life of approximately 10 hours after multiple…
Descarga: Pregnancy in Upshaw-Schulman syndrome Archivo: eha/vonwill/haemo 2013-Pregnancy in Upshaw-Schulman syndrome.pdf The Upshaw Schulman syndrome (MIM #274150) is a hereditary deficiency of the von Willebrand factor cleaving protease (ADAMTS13) due to homozygous or compound heterozygous mutations in the ADAMTS13 gene. Patients are prone to bouts of thrombotic thrombocytopenic purpura. However, disease manifestation needs a second…
Descarga: Coagulation factor XIII deficiency Archivo: ehh/haemo 2014-Coagulation factor XIII deficiency .pdf The plasma circulating zymogenic coagulation factor XIII (FXIII) is a protransglutaminase, which upon activation by thrombin and calcium cross-links preformed fibrin clots/fibrinolytic inhibitors making them mechanically stable and less susceptible to fibrino lysis. The zymogenic plasma FXIII molecule is a heterotetramer composed of…
Descarga: Perioperative management of patients who are receiving warfarin therapy: an evidence-based and practical approach Archivo: guias/varias/Warfarina manejo perioperatorio guias.pdf The management of patients who are receiving anticoagulants and require surgery or an invasive procedure is a common clinical problem that, paradoxically, is both trivial and complex.1,2 It istrivial because stopping and resuming an anticoagulant…
Descarga: Recommendations for endoscopy in the patient on chronic anticoagulation: apply with care! Archivo: guias/varias/PRECAUCIN CON LAS GUIAS.pdf With the escalating performance of colonoscopy in the United States over the past several years, there has been a consequent increase in the detection and the endoscopic removal of colonic polyps. Because colonic neoplasia is largely an…
Descarga: Apixaban Archivo: tromboembolia-venosa/haemo 2012-apixaban.pdf Apixaban is a potent reversible inhibitor of the activated human coagulation factor X. This new oral anticoagulant has favourable pharmacokinetic and pharmocodynamic properties which include a concentration-dependent anticoagulant effect, good oral bioavailability, balanced elimination and excretion, infrequent drug or food interactions, and the lack of liver toxicity. Apixaban has already…
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