Descarga: Antithrombin: anti-inflammatory properties and clinical applications Archivo: tromboembolia-venosa/th_2016-Antithrombin anti-inflammatory properties and.pdf Many humoral and cellular components participate in bidirectional communication between the coagulation and inflammation pathways. Natural anticoagulant proteins, including antithrombin (AT), tissue factor pathway inhibitor, and protein C, suppress proinflammatory mediators. Conversely, inflammation blunts anticoagulant activity and, when uncontrolled, promotes systemic inflammation-induced coagulation,…

Descarga: Age dependency for coagulation parameters in paediatric populations Archivo: tromboembolia-venosa/infancia/th_2016-Age dependency for coagulation parameters in paediatric populations .pdf Understanding of developmental haemostasis is critical to ensure optimal prevention, diagnosis, and treatment of haemorrhagic and thrombotic diseases in children. As coagulation test results are known to be dependent on the reagents/analysers used, it is recommended…

Descarga: Platelets in cancer Archivo: tromboembolia-venosa/tvp/haemo_2015-platelet in cancer.pdf Platelets are well-known for their major role in primary hemostasis and thrombosis. Cancer patients frequently manifest thrombotic events and present abnormalities in blood coagulation which appear to be linked to altered platelet function and turnover. Moreover, numerous studies indicate an intimate cross-talk between platelets and tumor growth,…

Descarga: VTE risk assessment in cancer Archivo: tromboembolia-venosa/tvp/haemo_2015-VTE risk assessment in cancer.pdf Venous thromboembolism (VTE) in patients with cancer is associated with an increased morbidity and mortality, and its prevention is of major clinical importance. However, the VTE rates in the cancer population vary between 0.5% – 20%, depending on cancer-, treatment- and patient-related factors….

Descarga: Platelet-derived chemokines in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-Platelet-derived chemokines in atherosclerosis.pdf In atherosclerosis, activated platelets have been recently recognised not only to participate in thrombotic events but also to play an essential role in the development of atherosclerotic lesions. Upon their activation, platelets release several pro-inflammatory mediators including chemokines. Chemokines are key molecules in inflammation as…

Descarga: Update on antithrombin I (fibrin) Archivo: tromboembolia-venosa/tvp/th_2007-Update on antithrombin I fibrin.pdf Antithrombin I (fibrin) is an important inhibitor of thrombin generation that functions by sequestering thrombin in the forming fibrin clot, and also by reducing the catalytic activity of fibrinbound thrombin.Thrombin binding to fibrin takes place at two classes of non-substrate sites: 1) in…

Descarga: The role of mast cells in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-The role of mast cells in atherosclerosis.pdf Rupture of an atherosclerotic plaque is the major underlying cause of adverse cardiovascular events such as myocardial infarction or stroke. Therapeutic interventions should therefore be directed towards inhibiting growth of atherosclerotic lesions as well as towards prevention of lesion…