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Problems and Solutions in Laboratory Testing for Hemophilia

Descarga: Problems and Solutions in Laboratory Testing for Hemophilia Archivo: tromboembolia-venosa/tvp/STH 2013 Problems and Solutions Lab testing.pdf  A diagnosis of hemophilia A or hemophilia B begins with clinical assessment of the patientandisfacilitatedbylaboratorytesting.Theinfluenceofthelatteronadiagnosis ofhemophiliaAorhemophiliaBisclear—adiagnosiscannotbemadewithoutlaboratory confirmation of a deficiency of factor FVIII (FVIII) or factor IX (FIX), respectively. Moreover, the degree of hemophilia severity is specifically characterized…

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Neutrophils in atherosclerosis

Descarga: Neutrophils in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-Neutrophils in atherosclerosis.pdf Atherosclerosis is a chronic inflammation of the arterial wall and the continuous infiltration of leukocytes into the plaque enhances the progression of the lesion. Because of the scarce detection of neutrophils in atherosclerotic plaques compared to other immune cells, their contribution was largely neglected. However, in the…

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VTE risk assessment in cancer

Descarga: VTE risk assessment in cancer Archivo: tromboembolia-venosa/tvp/haemo_2015-VTE risk assessment in cancer.pdf Venous thromboembolism (VTE) in patients with cancer is associated with an increased morbidity and mortality, and its prevention is of major clinical importance. However, the VTE rates in the cancer population vary between 0.5% – 20%, depending on cancer-, treatment- and patient-related factors….

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The role of mast cells in atherosclerosis

Descarga: The role of mast cells in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-The role of mast cells in atherosclerosis.pdf Rupture of an atherosclerotic plaque is the major underlying cause of adverse cardiovascular events such as myocardial infarction or stroke. Therapeutic interventions should therefore be directed towards inhibiting growth of atherosclerotic lesions as well as towards prevention of lesion…

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The function of ultra-large von Willebrand factor multimers in high shear flow controlled by ADAMTS13

Descarga: The function of ultra-large von Willebrand factor multimers in high shear flow controlled by ADAMTS13 Archivo: eha/vonwill/haemo_2015-The function of ultra-large VWF multimers in .pdf The paradigm that platelet aggregation, which contributes to bleeding arrest and also to thrombovascular disorders, initiates after signaling-induced platelet activation has been refuted in past recent years. Platelets can form…

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Treatment of von Willebrand Disease

Descarga: Treatment of von Willebrand Disease Archivo: eha/vonwill/STH 2016 treatment of VWD.pdf Congenital von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS) reflect conditions caused by von Willebrand factor (VWF) deficiency and/or defects.VWDisthemostcommoninheritedbleedingdisorderandAVWSarisesfroma variety of causes. Since VWF stabilizes and protects factor VIII (FVIII) in the circulation, this is also reduced in many patients…

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Platelet-derived chemokines in atherosclerosis

Descarga: Platelet-derived chemokines in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-Platelet-derived chemokines in atherosclerosis.pdf In atherosclerosis, activated platelets have been recently recognised not only to participate in thrombotic events but also to play an essential role in the development of atherosclerotic lesions. Upon their activation, platelets release several pro-inflammatory mediators including chemokines. Chemokines are key molecules in inflammation as…

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Recombinant clotting factors

Descarga: Recombinant clotting factors Archivo: ehh/th_2008-Recombinant clotting factors.pdf The recombinant era for haemophilia began in the early 1980s with the cloning and subsequent expression of functional proteins for both factors VIII and IX. Efficient production of recombinant clotting factors in mammalian cell culture systems required overcoming significant challenges due to the complex post-translational modifications that…

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Interference in Coagulation Testing: Focus on Spurious Hemolysis, Icterus, and Lipemia

Descarga: Interference in Coagulation Testing: Focus on Spurious Hemolysis, Icterus, and Lipemia Archivo: tromboembolia-venosa/tvp/STH 2013 Interference in Coagulation Testing.pdf The chance that errors might jeopardize the quality of testing is inherently present throughout the total testing process, especially in the preanalytical phase. In the coagulation laboratory, as well as in other areas of diagnostic testing,…

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What drives „fibrinolysis“?

Descarga: What drives „fibrinolysis“? Archivo: eha/Fibrinolosis/haemo_2015-what drives fibrinolysis.pdf The timely removal of blood clots and fibrin deposits is essential in the regulation of haemostasis. This is achieved by the fibrinolytic system, an enzymatic process that regulates the activation of plasminogen into its proteolytic form, plasmin. This is a self-regulated event as the very presence of…

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