Descarga: The role of mast cells in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-The role of mast cells in atherosclerosis.pdf Rupture of an atherosclerotic plaque is the major underlying cause of adverse cardiovascular events such as myocardial infarction or stroke. Therapeutic interventions should therefore be directed towards inhibiting growth of atherosclerotic lesions as well as towards prevention of lesion…
Descarga: Type 2M and Type 2A von Willebrand Disease: Similar but Different Archivo: eha/vonwill/STH 2016 2M vs 2A VWD.pdf Analogous to the differentiation between hemophilia A and B, respectively, reflecting deficiency in factor VIII (FVIII) and FIX, and increasing being recognized as reflecting clinicallydifferentdisorders,types2Aand2MvonWillebranddisease(VWD)canalsobe shown to express both similarities and differences in their prevalence, genetic…
Descarga: Recombinant clotting factors Archivo: ehh/th_2008-Recombinant clotting factors.pdf The recombinant era for haemophilia began in the early 1980s with the cloning and subsequent expression of functional proteins for both factors VIII and IX. Efficient production of recombinant clotting factors in mammalian cell culture systems required overcoming significant challenges due to the complex post-translational modifications that…
Descarga: What drives „fibrinolysis“? Archivo: eha/Fibrinolosis/haemo_2015-what drives fibrinolysis.pdf The timely removal of blood clots and fibrin deposits is essential in the regulation of haemostasis. This is achieved by the fibrinolytic system, an enzymatic process that regulates the activation of plasminogen into its proteolytic form, plasmin. This is a self-regulated event as the very presence of…
Descarga: Platelet-derived chemokines in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-Platelet-derived chemokines in atherosclerosis.pdf In atherosclerosis, activated platelets have been recently recognised not only to participate in thrombotic events but also to play an essential role in the development of atherosclerotic lesions. Upon their activation, platelets release several pro-inflammatory mediators including chemokines. Chemokines are key molecules in inflammation as…
Descarga: Treatment of von Willebrand Disease Archivo: eha/vonwill/STH 2016 treatment of VWD.pdf Congenital von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS) reflect conditions caused by von Willebrand factor (VWF) deficiency and/or defects.VWDisthemostcommoninheritedbleedingdisorderandAVWSarisesfroma variety of causes. Since VWF stabilizes and protects factor VIII (FVIII) in the circulation, this is also reduced in many patients…
Descarga: The function of ultra-large von Willebrand factor multimers in high shear flow controlled by ADAMTS13 Archivo: eha/vonwill/haemo_2015-The function of ultra-large VWF multimers in .pdf The paradigm that platelet aggregation, which contributes to bleeding arrest and also to thrombovascular disorders, initiates after signaling-induced platelet activation has been refuted in past recent years. Platelets can form…
Descarga: New agents for thromboprotection Archivo: tromboembolia-venosa/tvp/haemo_2015-New agents for thromboprotection.pdf Blood coagulation is essential for hemostasis, however excessive coagulation can lead to thrombosis. Factor XII starts the intrinsic coagulation pathway and contact-induced factor XII activation provides the mechanistic basis for the diagnostic aPTT clotting assay. Despite its function for fibrin formation in test tubes, patients…
Descarga: Problems and Solutions in Laboratory Testing for Hemophilia Archivo: tromboembolia-venosa/tvp/STH 2013 Problems and Solutions Lab testing.pdf A diagnosis of hemophilia A or hemophilia B begins with clinical assessment of the patientandisfacilitatedbylaboratorytesting.Theinfluenceofthelatteronadiagnosis ofhemophiliaAorhemophiliaBisclear—adiagnosiscannotbemadewithoutlaboratory confirmation of a deficiency of factor FVIII (FVIII) or factor IX (FIX), respectively. Moreover, the degree of hemophilia severity is specifically characterized…
Descarga: Platelets in cancer Archivo: tromboembolia-venosa/tvp/haemo_2015-platelet in cancer.pdf Platelets are well-known for their major role in primary hemostasis and thrombosis. Cancer patients frequently manifest thrombotic events and present abnormalities in blood coagulation which appear to be linked to altered platelet function and turnover. Moreover, numerous studies indicate an intimate cross-talk between platelets and tumor growth,…
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