Descarga: Platelet pathology and antiplatelet strategies Archivo: eha/plaquetopatias/haemo 2016 Platelet pathology and antiplatelet strategies.pdf Blood platelets were the focus of recent issues of this Journal (1, 2). Why do these inconspicuous, small cellular fragments, derived from megakaryocytes in the bone marrow, gain so much attention both in clinical settings and basic science? Platelets contribute essentially…
Descarga: Interaction of von Willebrand factor with platelets and the vessel wall Archivo: tromboembolia-arterial/haemo_2015-Atherogenesis and inflammation.pdf The initiation of thrombus formation at sites of vascular injury to secure haemostasis after tissue trauma requires the interaction of surface-exposed von Willebrand factor (VWF) with its primary platelet receptor, the glycoprotein (GP) Ib-IX-V complex. As an insoluble component…
Descarga: Management of bleeding with oral anticoagulants in patients with atrial fibrillation Archivo: tromboembolia-venosa/tvp/haemo_2015-Management of bleeding with oral anticoagulants in.pdf Fear of bleeding is a common barrier to the use of anticoagulants. Warfarin has been the only oral anticoagulant for more than 60 years and warfarin-related bleeding is reported to be the most common drug-related…
Descarga: Monocyte subsets in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-monocyte in atherosclerosis.pdf Endothelial dysfunction and chronic inflammation of the arterial wall continuously drive the development of atherosclerotic lesions. Monocytes, as cells of the innate immunity, are particularly involved in this process. In the last decade, heterogeneity of circulating monocytes has widely been acknowledged, and a recent consensus nomenclature…
Descarga: Individualized antithrombotic therapy Archivo: tromboembolia-venosa/haemo 2016 individualized antithrombotic therapy.pdf Clot formation in the circulation is a physiological mechanism preventing bleeding at sites of loss of vascular integrity. Clot formation may also occur intravascularly under pathological conditions, e. g. leading to myocardial infarction, stroke, and critical limb ischaemia. Clot formation involves activation of the coagulation…
Descarga: Heparin induced thrombocytopeni Archivo: tromboembolia-venosa/tvp/haemo 2015-Heparin induced thrombocytopenia.pdf Heparin induced thrombocytopenia (HIT) is a prothrombotic syndrome initiated by platelet-activating auto-antibodies with potentially devastating complications. Once the diagnosis of HIT is suspected, discontinuation of heparin and treatment with an alternative anticoagulant are mandatory. While established drugs for HIT are no longer available, parenteral factor Xa…
Descarga: Management of acquired haemophilia A Archivo: eha/inhibfact/haemo 2015-Management of acquired haemophilia A.pdf Acquired haemophilia A (AHA) is caused by autoantibody inhibitors of coagulation factor VIII (FVIII : C). Recent onset of bleeds and isolated prolongation of the activated partial thromboplastin time (aPTT) are characteristic features of the disorder. Reduced FVIII : C activity and…
Descarga: Individualized antithrombotic therapy Archivo: tromboembolia-venosa/haemo 2016 individualized antithrombotic therapy.pdf Clot formation in the circulation is a physiological mechanism preventing bleeding at sites of loss of vascular integrity. Clot formation may also occur intravascularly under pathological conditions, e. g. leading to myocardial infarction, stroke, and critical limb ischaemia. Clot formation involves activation of the coagulation…
Descarga: Genetics of inherited platelet disorders Archivo: eha/plaquetopatias/haemo 2014-Genetics of inherited platelet disorders.pdf The current review describes inherited platelet disorders, illustrates their clinical phenotype and molecular genetic defects. Platelets are the key molecules mediating haemostasis via adhesion, activation and clot formation at the site of injury. The inherited platelet disorders can be classified according to…
Descarga: Biomarkers for arterial and venous thrombotic disorders Archivo: tromboembolia-venosa/haemo_2014-Biomarkers for arterial and venous thrombotic disorders.pdf The haemostatic system maintains the blood in a fluid state, but allows rapid clot formation at sites of vascular injury to prevent excessive bleeding. Unbalances within the haemostatic system can lead to thrombosis. Inspite of successful research our understanding…
Por favor inicie sesión