Pregnancy in Upshaw-Schulman syndrome
Descarga: Pregnancy in Upshaw-Schulman syndrome Archivo: eha/vonwill/haemo 2013-Pregnancy in Upshaw-Schulman syndrome.pdf The Upshaw Schulman syndrome (MIM #274150) is a hereditary deficiency of the von Willebrand factor cleaving protease (ADAMTS13) due to homozygous or compound heterozygous mutations in the ADAMTS13 gene. Patients are prone to bouts of thrombotic thrombocytopenic purpura. However, disease manifestation needs a second…
Perioperative management of patients who are receiving warfarin therapy: an evidence-based and practical approach
Descarga: Perioperative management of patients who are receiving warfarin therapy: an evidence-based and practical approach Archivo: guias/varias/Warfarina manejo perioperatorio guias.pdf The management of patients who are receiving anticoagulants and require surgery or an invasive procedure is a common clinical problem that, paradoxically, is both trivial and complex.1,2 It istrivial because stopping and resuming an anticoagulant…
Coagulation factor XIII deficiency
Descarga: Coagulation factor XIII deficiency Archivo: ehh/haemo 2014-Coagulation factor XIII deficiency .pdf The plasma circulating zymogenic coagulation factor XIII (FXIII) is a protransglutaminase, which upon activation by thrombin and calcium cross-links preformed fibrin clots/fibrinolytic inhibitors making them mechanically stable and less susceptible to fibrino lysis. The zymogenic plasma FXIII molecule is a heterotetramer composed of…