Descarga: The role of mast cells in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-The role of mast cells in atherosclerosis.pdf Rupture of an atherosclerotic plaque is the major underlying cause of adverse cardiovascular events such as myocardial infarction or stroke. Therapeutic interventions should therefore be directed towards inhibiting growth of atherosclerotic lesions as well as towards prevention of lesion…
Descarga: New agents for thromboprotection Archivo: tromboembolia-venosa/tvp/haemo_2015-New agents for thromboprotection.pdf Blood coagulation is essential for hemostasis, however excessive coagulation can lead to thrombosis. Factor XII starts the intrinsic coagulation pathway and contact-induced factor XII activation provides the mechanistic basis for the diagnostic aPTT clotting assay. Despite its function for fibrin formation in test tubes, patients…
Descarga: Platelet Membrane Glycoproteins: A Historical Review Archivo: tromboembolia-venosa/tvp/STH 2014 Interference in Coagulation Testing.pdf The search for the components of the platelet surface that mediate platelet adhesion andplateletaggregationbeganforearnestinthelate1960swhenelectronmicroscopy demonstrated the presence of a carbohydrate-rich, negatively charged outer coat that was called the “glycocalyx.” Progressively, electrophoretic procedures were developed that identified the major membrane glycoproteins (GP)…
Descarga: Type 2M and Type 2A von Willebrand Disease: Similar but Different Archivo: eha/vonwill/STH 2016 2M vs 2A VWD.pdf Analogous to the differentiation between hemophilia A and B, respectively, reflecting deficiency in factor VIII (FVIII) and FIX, and increasing being recognized as reflecting clinicallydifferentdisorders,types2Aand2MvonWillebranddisease(VWD)canalsobe shown to express both similarities and differences in their prevalence, genetic…
Descarga: Individualized antithrombotic therapy Archivo: tromboembolia-venosa/haemo 2016 individualized antithrombotic therapy.pdf Clot formation in the circulation is a physiological mechanism preventing bleeding at sites of loss of vascular integrity. Clot formation may also occur intravascularly under pathological conditions, e. g. leading to myocardial infarction, stroke, and critical limb ischaemia. Clot formation involves activation of the coagulation…
Descarga: Evolución del conocimiento sobre la sangre y su movimiento. Parte II Archivo: historia/Composicion sangre II.pdf Conocer de que está hecha la sangre y cuáles son los beneficios que sus componentes prestan a la vida fue una interrogante que estimuló por siglos la curiosidad de los investigadores. Cada una de las épocas del saber humano…
Descarga: Management of bleeding with oral anticoagulants in patients with atrial fibrillation Archivo: tromboembolia-venosa/tvp/haemo_2015-Management of bleeding with oral anticoagulants in.pdf Fear of bleeding is a common barrier to the use of anticoagulants. Warfarin has been the only oral anticoagulant for more than 60 years and warfarin-related bleeding is reported to be the most common drug-related…
Descarga: Interaction of von Willebrand factor with platelets and the vessel wall Archivo: tromboembolia-arterial/haemo_2015-Atherogenesis and inflammation.pdf The initiation of thrombus formation at sites of vascular injury to secure haemostasis after tissue trauma requires the interaction of surface-exposed von Willebrand factor (VWF) with its primary platelet receptor, the glycoprotein (GP) Ib-IX-V complex. As an insoluble component…
Descarga: El Grupo Cooperativo Latinoamericano de Hemostasia y Trombosis (CLAHT). Historia y perspectiva Archivo: historia/Historia del Claht.pdf El Grupo Cooperativo Latinoamericano de Hemostasia y Trombosis (CLAHT) lo fundaron, oficialmente, en 1976, varios profesionales expertos en hemostasia y trombosis. Este grupo se conformó como parte de las actividades académicas de la International Society of Hematology (ISH)…
Descarga: Monocyte subsets in atherosclerosis Archivo: tromboembolia-venosa/tvp/haemo_2015-monocyte in atherosclerosis.pdf Endothelial dysfunction and chronic inflammation of the arterial wall continuously drive the development of atherosclerotic lesions. Monocytes, as cells of the innate immunity, are particularly involved in this process. In the last decade, heterogeneity of circulating monocytes has widely been acknowledged, and a recent consensus nomenclature…
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