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Cancer-associated venous thromboembolism: Burden, mechanisms, and management

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Descarga: Cancer-associated venous thromboembolism: Burden, mechanisms, and management Archivo: tromboembolia-venosa/tvp/th_2017-Cancer-associated venous thromboembolism.pdf Venous thromboembolism (VTE) is a significant health problem in the general population but especially in cancer patients. In this review, we discuss the epidemiology and burden of the disease, the pathophysiology of cancer-associated VTE, and the clinical treatment options for both primary prevention…

Cirrhosis as a risk factor for venous thrombosis

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Descarga: Cirrhosis as a risk factor for venous thrombosis Archivo: tromboembolia-venosa/tvp/th_2017-Cirrhosis as a risk factor for venous thrombosis.pdf Chronic and acute liver diseases have long been considered as the epitome of acquired bleeding disorders. Evidence in support of this included profoundly abnormal test results of routine diagnostic tests of haemostasis in combination with clinical bleeding…

A Brief Historical Review of the Waterfall/Cascade of Blood Coagulation

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Descarga: A Brief Historical Review of the Waterfall/Cascade of Blood Coagulation Archivo: historia/Historia cascada coagulacion.pdf This article explores some of the events and people involved in unraveling the basic mechanisms leading to the clotting of blood. It also brings to focus the important role that my teachers and colleagues had on my career in research….

The best of times, the worst of times: a story of haemophilia

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Descarga: The best of times, the worst of times: a story of haemophilia Archivo: historia/HISTORIA DE LA HEMOFILIA.pdf It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity, it…

The history of haemophilia

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Descarga: The history of haemophilia Archivo: historia/IngramHistoria Hemofilia1976.pdf The history of haemophilia shows the human mind attempting to define and encompass a mysterious yet fascinating phenomenon; and also the human heart responding to the challenge of repeated adversity. These responses have not remained isolated but have frequently interacted. As doctors have studied haemophilia in order…

Oxford, the Mecca for blood coagulation research in the 1950s and 1960s

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Descarga: Oxford, the Mecca for blood coagulation research in the 1950s and 1960s Archivo: historia/OxfordLa Meca de lacoagulacion.pdf Gwyn Macfarlane was undoubtedly the instigator of blood coagulation research at Oxford during the last century. From his earliest paper in 1931 on a survey of hemophilia [1], he engendered an interest in the diagnosis and treatment…

The various states of von Willebrand factor and their function in physiology and pathophysiology

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Descarga: The various states of von Willebrand factor and their function in physiology and pathophysiology Archivo: eha/vonwill/th_2014-The various states of VWF and their function2.pdf The specific interactions of von Willebrand factor (VWF) with the vessel wall, platelets or other interfaces strongly depend on (a shearinduced) VWF activation. Shear flow has been shown to induce a…

Exploring unmet needs in venous and arterial thromboembolism with rivaroxaban

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Descarga: Exploring unmet needs in venous and arterial thromboembolism with rivaroxaban Archivo: tromboembolia-venosa/tvp/th_2016-116-Suppl. 2_26558.pdf The vast clinical research programme for the direct, oral factor Xa inhibitor rivaroxaban has generated a wealth of data since the first rivaroxaban approval in 2008 for the prevention of venous thrombo embolism (VTE) in patients undergoing elective hip or knee…

Exploring unmet needs in venous and arterial thromboembolism with rivaroxaban

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Descarga: Exploring unmet needs in venous and arterial thromboembolism with rivaroxaban Archivo: tromboembolia-venosa/tvp/th_2016-116-Suppl. 2_26558.pdf The vast clinical research programme for the direct, oral factor Xa inhibitor rivaroxaban has generated a wealth of data since the first rivaroxaban approval in 2008 for the prevention of venous thrombo embolism (VTE) in patients undergoing elective hip or knee…

Age dependency for coagulation parameters in paediatric populations

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Descarga: Age dependency for coagulation parameters in paediatric populations Archivo: tromboembolia-venosa/infancia/th_2016-Age dependency for coagulation parameters in paediatric populations .pdf Understanding of developmental haemostasis is critical to ensure optimal prevention, diagnosis, and treatment of haemorrhagic and thrombotic diseases in children. As coagulation test results are known to be dependent on the reagents/analysers used, it is recommended…