Descarga: Exploring unmet needs in venous and arterial thromboembolism with rivaroxaban Archivo: tromboembolia-venosa/tvp/th_2016-116-Suppl. 2_26558.pdf The vast clinical research programme for the direct, oral factor Xa inhibitor rivaroxaban has generated a wealth of data since the first rivaroxaban approval in 2008 for the prevention of venous thrombo embolism (VTE) in patients undergoing elective hip or knee…
Descarga: Age dependency for coagulation parameters in paediatric populations Archivo: tromboembolia-venosa/infancia/th_2016-Age dependency for coagulation parameters in paediatric populations .pdf Understanding of developmental haemostasis is critical to ensure optimal prevention, diagnosis, and treatment of haemorrhagic and thrombotic diseases in children. As coagulation test results are known to be dependent on the reagents/analysers used, it is recommended…
Descarga: Antithrombin: anti-inflammatory properties and clinical applications Archivo: tromboembolia-venosa/th_2016-Antithrombin anti-inflammatory properties and.pdf Many humoral and cellular components participate in bidirectional communication between the coagulation and inflammation pathways. Natural anticoagulant proteins, including antithrombin (AT), tissue factor pathway inhibitor, and protein C, suppress proinflammatory mediators. Conversely, inflammation blunts anticoagulant activity and, when uncontrolled, promotes systemic inflammation-induced coagulation,…
Descarga: Clinical and laboratory tests for the diagnosis of heparin-induced thrombocytopenia Archivo: tromboembolia-venosa/tvp/th_2016-Clinical and laboratory tests for the diagnosis of heparin-induced thrombocytopenia.pdf A rapid diagnostic work-up is required in patients with suspected heparin-induced thrombocytopenia (HIT). However, diagnosis of HIT is challenging due to a number of practical issues and methodological limitations. Many laboratory tests and…
Descarga: What drives „fibrinolysis“? Archivo: eha/Fibrinolosis/haemo_2015-what drives fibrinolysis.pdf The timely removal of blood clots and fibrin deposits is essential in the regulation of haemostasis. This is achieved by the fibrinolytic system, an enzymatic process that regulates the activation of plasminogen into its proteolytic form, plasmin. This is a self-regulated event as the very presence of…
Descarga: Clinical trials with new direct oral anticoagulants Archivo: tromboembolia-venosa/tvp/Phlebologie 03_2013 clinical trials DOA.pdf To compare the efficacy and safety of the new direct oral anticoagulants (DOAC), ideally head-to-head clinical trials should be performed. Given the expense of such an undertaking, it is highly unlikely that such a comparison would be performed. Therefore, there is…
Descarga: Interference in Coagulation Testing: Focus on Spurious Hemolysis, Icterus, and Lipemia Archivo: tromboembolia-venosa/tvp/STH 2013 Interference in Coagulation Testing.pdf The chance that errors might jeopardize the quality of testing is inherently present throughout the total testing process, especially in the preanalytical phase. In the coagulation laboratory, as well as in other areas of diagnostic testing,…
Descarga: Problems and Solutions in Laboratory Testing for Hemophilia Archivo: tromboembolia-venosa/tvp/STH 2013 Problems and Solutions Lab testing.pdf A diagnosis of hemophilia A or hemophilia B begins with clinical assessment of the patientandisfacilitatedbylaboratorytesting.Theinfluenceofthelatteronadiagnosis ofhemophiliaAorhemophiliaBisclear—adiagnosiscannotbemadewithoutlaboratory confirmation of a deficiency of factor FVIII (FVIII) or factor IX (FIX), respectively. Moreover, the degree of hemophilia severity is specifically characterized…
Descarga: Diagnosing von Willebrand Disease: A Short History of Laboratory Milestones and Innovations, Plus Current Status, Challenges, and Solutions Archivo: eha/vonwill/STH 2014 Diagnosing von Willebrand Disease.pdf von Willebrand disease (VWD) is a disorder characterized by deficiency of, or defects in, von Willebrand factor (VWF). VWD was originally identified by Erik Adolf von Willebrand, who in…
Descarga: Type 2M and Type 2A von Willebrand Disease: Similar but Different Archivo: eha/vonwill/STH 2016 2M vs 2A VWD.pdf Analogous to the differentiation between hemophilia A and B, respectively, reflecting deficiency in factor VIII (FVIII) and FIX, and increasing being recognized as reflecting clinicallydifferentdisorders,types2Aand2MvonWillebranddisease(VWD)canalsobe shown to express both similarities and differences in their prevalence, genetic…
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